Butterfly Wings, Benedykt R. Jany, Marian SmoluchowskiInstitute of Physics - Jagiellonian University, Poland Diatoms World, Mostafa Moonir Shawrav, Institute of Solid State Electronics, Austria Scabiosa columbaria - Viktor Sykora, Charles University, Věda je krásná
Leaf Fract, TESCAN1- CVD grown diamond film, Magdalena Parlinska, University of Rzeszow, Poland Rhaphoneis - Pavel Skaloud, Charles University, Věda je krásná
3- Diatom, Magdalena Parlinska, University of Rzeszow, Poland Scenedesmus quadricauda - Viktor Sykora, Charles University , Věda je krásnáPaulinella chromatophora - Yvonne Nemcova, Charles University, Věda je krásná
2- Diatom, Magdalena Parlinska, University of Rzeszow, Poland Procapsid and nucleocapsid of dsRNA bacteriophage phi6, D. Nemecek, CryoEM Research Group CEITEC, Czech Republic Pollen grain of Hyoseris radiata, TESCAN
Rust fungus spore,Adriana Dominguez and Eduardo Favret, CNEA - INTA, Argentina.jpg Coral, TESCANSalt, TESCAN
SEM image of ink-bottle silica nanopores, A. Sterczynska,NanoBioMediacl Centre (CNBM), Poznan, Poland Orchid root stained with Acridine orange, S. R. Senthilkumar, St. Joseph´s College, India Powder metallurgy substrate, TESCAN
Rotaviruses, Electronmicroscopy, Elisabeth M. Schraner, Institutes of Vet. Anatomy and Virology, Switzerland Chroococcus giganteus - Jan Stastny, Charles University, Věda je krásnáCross section of an Abutilon leaf, Adriana Dominguez and Eduardo Favret, CNEA - INTA, Argentina

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DSCN0721.JPGThe Eduard Kellenberger Medal
Dr. Alasdair Steven
Laboratory of Structural Biology, National Institute for Arthritis, Musculoskeletal and Skin Diseases NIH, Bethesda, MD, USA

Macromolecules in Motion: Visualization by 4-Dimensional CRYO-EM
Date: Friday, 12 September 2014, 11:10–12:00
Room: Congress Hall

Present Position
Chief – Laboratory of Structural Biology Research, NIAMS/NIH, 9000 Rockville Pike, Bethesda, MD 20892,USA

Higher Education
1965–1969 Edinburgh University, U.K. – M.A. – 1st Class Honours, Summa cum Laude (6/69).
1969–1970 St. John's College, Cambridge University, U.K. – Part III of Mathematical Tripos (6/70), General relativity, cosmology, advanced quantum theory. Thesis: "Gravitational Collapse"
1970–1973 Cambridge University, U.K. – Ph.D. (9/73) : Theoretical elementary particle physics. Supervisor: Dr. R.J. Eden, Cavendish Laboratory. Thesis: "Limiting High-Energy Behaviour of Hadronic Total Cross-sections and Production Phenomena"

Postdoctoral Training
1973–78 Biozentrum, Basel University, Switzerland, SKMB Certif icate in Molecular Biology (9/75). Supervisor: Prof. E. Kellenberger, Dept. of Microbiology. Thesis: "Form Determination and Proteolytic Transformation of the P23 Surface Shell of the Polyheads of Bacteriophage T4"

Senior Scholar – Humboldt Foundation, Germany (2000–2005)
Fellow – American Academy for Microbiology (1999–present)
Adjunct Professor – Department of Chemistry and Biochemistry, University of Maryland, College Park, MD (2004–2009)
Medal of First Medical Faculty, Charles University, Prague (11/2005)
Pace lecturer, Department of Biochemistry, University of Utah (3/2007)
Distinguished Scientist (Biology), Microscopy Society of America (7/2008)

Research Interests

Structure, assembly, regulation and dynamics of macromolecular assemblies: primarily, viruses, cytoskeletal f ilaments, ATPase-assisted proteases, prions and amyloids. Biological electron microscopy, specimen preparation, digital image processing. Hybrid methods of structural analysis integrating EM with other biophysical techniques.

Total publications
309 (peer-reviewed primary research papers, 83%). Total citations: 14,750 H-index : 70

List of publications (selected):

A.C. Steven, E. Couture, U. Aebi & M.K. Showe. A Pathway of Polyhead Transformations as a Model for T4 Capsid Maturation. J. Mol. Biol. 106:187-221 (1976).

A.C. Steven, J.F. Hainfeld, B.L. Trus, J.S. Wall & P.M. Steinert. Epidermal Keratin Filaments Assembled in vitro have Masses-per-Unit-Length that Scale According to Average Subunit Mass: Structural Basis for Homologous Packing of Subunits in Intermediate Filaments. J. Cell Biol. 97:1939-1944 (1983).

F.P. Booy, W.W. Newcomb, B.L. Trus, J.C. Brown, T.S. Baker & A.C. Steven. Liquid-crystalline, Phage-like, Packing of Encapsidated DNA in Herpes Simplex Virus. Cell 64:1007-1015 (1991).

B.L. Trus, F.P. Booy, W.W. Newcomb, J.C. Brown, F.L. Homa, D.R. Thomsen & A.C. Steven. The Herpes Simplex Virus Procapsid: Structure, Conformational Changes upon Maturation, and Roles of the Triplex Proteins VP19c and VP23 in Assembly. J. Mol. Biol. 263:447-462 (1996).

J.F. Conway, N. Cheng, A. Zlotnick, P.T. Wingfield, S.J. Stahl & A.C. Steven. Visualization of a 4-Helix Bundle in the Hepatitis B Virus Capsid by Cryo-electron Microscopy. Nature 386:91-94 (1997).

F. Beuron, M.R. Maurizi, D.M. Belnap, E. Kocsis, F.P. Booy, M. Kessel & A.C. Steven. At Sixes and Sevens: Characterization of the Symmetry Mismatch of the ClpAP Chaperone-assisted Protease. J. Struct. Biol. 123, 248-259 (1998).

T. Ishikawa, F. Beuron, M. Kessel, S. Wickner, M.R. Maurizi & A.C. Steven. Translocation Pathway of Protein Substrates in ClpAP Protease. Proc. Nat'l. Acad. Sci. USA 98: 4328-4333 (2001).

J.F. Conway, W.R. Wikoff, N. Cheng, R.L. Duda, R.W. Hendrix, J.E. Johnson & A.C. Steven. Virus Maturation via a Conformational Change Involving Large Subunit Rotations and Local Refolding. Science 292: 744-748 (2001).

J.B. Heymann, N. Cheng, W.W. Newcomb, B.L.Trus, J.C. Brown & A.C. Steven. Dynamics of Herpes Simplex Virus Capsid Maturation Visualized by Time-Lapsed Cryo-EM. Nature Struct. Biol. 10, 334-341 (2003)

A.V. Kajava, U. Baxa, R.B. Wickner & A.C. Steven. A Model for Ure2p Prion Filaments and Other Amyloids: The Parallel Super-pleated -Structure. Proc. Nat'l. Acad. Sci. USA 101, 7885-7890 (2004).









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